Tyrosinosis (Inborn Hepato-Renal Dysfunction)

Updates on Hepato-Renal Syndrome.

Hepato-renal syndrome (HRS) is one of the most detrimental conditions in patients with end stage liver failure. Historically, HRS was considered a terminal disease associated with cirrhosis and was termed "liver-death syndrome". Furthermore, despite the improved understanding of pathophysiology and the reversibility of renal dysfunction in HRS, mortality remains extremely high especially for ty...

Pleurotus ostreatus opposes mitochondrial dysfunction and oxidative stress in acetaminophen-induced hepato-renal injury

BACKGROUND Acetaminophen (APAP)-induced toxicity is a predominant cause of acute hepatic and renal failure. In both humans and rodents toxicity begins with a reactive metabolite that binds to proteins. This leads to mitochondrial dysfunction and nuclear DNA fragmentation resulting in necrotic cell death. Pleurotus ostreatus (an edible oyster mushroom) is well recognized as a flavourful food, as...

Zellweger syndrome (cerebro-hepato-renal syndrome).

A syndrome with distinctive clinical features affecting brain, liver and kidneys was described by Bowen et al in 1964 1 and Smith et al. in 1965 2 . In 1973 Goldfisher et al 3 has reported that peroxisomes were absent in the liver and kidneys of affected children. More recently lack of dihydroxyacetone phosphate acyletransferase (DHAP-AT) a peroxisomal enzyme with a major role in glycerol ether...

Transjugular renal biopsy. Update on hepato-renal needlework.

In 1990, a poster presented at the American Society of Nephrology kindled curiosity [1]. The placard indicated that renal biopsy can be performed by puncturing the right kidney from inside, with a needle inserted along a catheter running from the jugular vein into the lower pole. Publications followed, from those who had broken new ground and thereafter from many members of the nephrological ci...

INBORN defects of the renal tubule.